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人体内microRNA抑制乳腺癌转移

标签: 人体 microRNA 抑制 乳腺癌转移

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世界著名抗肿瘤权威机构——纽约斯隆-凯特琳癌症中心(Memorial Sloan-Kettering Cancer Center)的研究人员在2008年1月出版Nature上发表了题为“Endogenous human microRNAs that suppress breast cancer metastasis”的microRNA研究论文。

研究人员使用包括microRNA微阵列检测技术(LC Sciences提供)在内的多种研究手段对人类癌症转移调节子进行了深入研究,发现了一系列microRNAs的异常表达与乳腺癌的转移密切相关,其中miR-335与miR-126对肿瘤转移的抑制发挥着关键性作用。

Endogenous human microRNAs that suppress breast cancer metastasis.

Nature. 2008 Jan 10; 451(7175):147-52

Tavazoie SF, Alarcón C, Oskarsson T, Padua D, Wang Q, Bos PD, Gerald WL, Massagué J.

A search for general regulators of cancer metastasis has yielded a set of microRNAs for which expression is specifically lost as human breast cancer cells develop metastatic potential. Here we show that restoring the expression of these microRNAs in malignant cells suppresses lung and bone metastasis by human cancer cells in vivo. Of these microRNAs, miR-126 restoration reduces overall tumour growth and proliferation, whereas miR-335 inhibits metastatic cell invasion. miR-335 regulates a set of genes whose collective expression in a large cohort of human tumours is associated with risk of distal metastasis. miR-335 suppresses metastasis and migration through targeting of the progenitor cell transcription factor SOX4 and extracellular matrix component tenascin C. Expression of miR-126 and miR-335 is lost in the majority of primary breast tumours from patients who relapse, and the loss of expression of either microRNA is associated with poor distal metastasis-free survival. miR-335 and miR-126 are thus identified as metastasis suppressor microRNAs in human breast cancer.

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